10. Santana Lopez, Glee
Played by the late Naya Rivera, Santana was the ultimate mean girl from 2009-2015. Just one cold stare from this beauty, and you know you’re in the doghouse. This cheerleader was all about being a straight shooter and taking down any enemies that might be in her way. A master at manipulation and an owner of a sharp tongue, she also had a more compassionate side that revealed itself over time, but it never made her weak.
